My absolute favorite twitter application is Twhirl. Actually Twhirl is more than just a twitter client as you can also use it to manage your online activities with:
I’ve only got accounts setup on twitter, FriendFeed and identi.ca though. The other benefit of a using a tool like Twhirl though is that you can also manage multiple accounts simultaneously. So you can have a personal and business account the same services.
The other benefit of using an application like Twhirl to manage your twitter account is that it assists you in quickly sorting and separating your replies and direct messages from other twitter users (tweeps).
One of the questions I have about Twhirl though is why I sporadically get this Twhirl explosion of notifications of replies and direct messages.
Anyone have an idea about that?